DNMT3A and acute myeloid leukemia: The best-studied epigenetic changes in cancer are the methylation changes that occur within the CpG island, and the next generation sequencing platform has now provided a genome-wide map of CpG methylation.[26] And, recent cancer genome sequencing has identified recurrent mutations in DNA methyltransferase 3A (DNMT3A) in up to 25% of patients with acute myeloid leukemia.