Conversely, FGF20 (OR 0.959, 95% CI: 0.920–0.999, P = .046) was found to reduce the risk of BC, with consistent results from the weighted median (OR 0.921, 95% CI: 0.864–0.982, P = .012) and MR-Egger (P = .550). This evidence concerns the gene FGF20 and breast cancer.