It has been pointed out that about 37% of undifferentiated and differentiated endometrial carcinomas (UDEC) also demonstrate biallelic inactivation of SMARCA4 and SMARCA2 and can exhibit a rhabdomyosiform morphology similar to that of SDUS.[6] However, SDUS is typically negative for epithelial markers, whereas more than 80% of UDEC express keratins.[4] Additionally, Next-Generation Sequencing has shown that, unlike SDUS, UDEC is usually MSI-H and mutations associated with endometrial cancer, such as PTEN and TP53. The gene discussed is PTEN; the disease is endometrial carcinoma.