In this case, the patient had elevated uric acid and did not receive thiazide diuretic treatment.[14] Renin-angiotensin system inhibitors may be employed to slow CKD progression.[15] Despite controversies surrounding the implementation of vitamin D supplementation, given the risk of increased intestinal Ca absorption and worsening hypercalciuria, vitamin D is also expected to lower PTH levels, thereby reducing hypercalciuria. The gene discussed is REN; the disease is Hypercalciuria.