Hyperuricemia and gout in adolescents typically indicate autosomal dominant tubular interstitial nephropathy (ADTKD).[4] Among these patients, the fraction of uric acid released by uromodulin-associated ADTKD is generally reduced (<5%), which promotes early hyperuricemia and gout, and there is also a family history of kidney disease. This evidence concerns the gene UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia.