REN and hyperhomocysteinemia: It is worth noting that recent studies, such as those conducted by the Al-Kuraishy team, have found that factors such as hyperhomocysteinemia, the classical and non-classical axes of the renin–angiotensin system, and abnormal prolactin levels are all closely related to the onset and progression of PD.[87–89] Additionally, the NF-κB/NLRP3 inflammasome axis plays a crucial role in patients with type 2 diabetes mellitus complicated by PD.[90] The revelation of these new mechanisms provides potential targets for the action of exercise rehabilitation training.