These chromosomes undergo amplification in the 12q13-15 region, encompassing crucial genes, such as MDM2, CDK4, HMGA2, and CPM.[15–17] Of these, MDM2 serves as the primary driver in ALT/WDLPS and DDLPS pathogenesis, with approximately a 100% amplification rate. The gene discussed is CDK4; the disease is dedifferentiated liposarcoma.