Another marker expressed in ACC with or without perineural spread is the brain‐derived neurotrophic factor.[9] E-cadherin has been shown to have reduced expression in progressive forms of ACC.[1] In the cohort, the main immunohistochemistry result was positive for Cytokeratin5/6, EMA, calponin, S-100, SMA, Cytokeratin8/18, Cytokeratin, Ki-67, CEA, Vimentin, and GFAP. The gene discussed is GFAP; the disease is adrenal cortex carcinoma.