Widely studied in cardiovascular disease, MALAT1 is highly expressed in the peripheral vasculature, where it regulates coronary artery smooth muscle cell proliferation and migration.[42] Endothelial injury induced by inflammation is a central driver of stent restenosis, and MALAT1 – abundantly expressed in endothelial cells – has been linked to endothelial dysfunction, inflammatory signaling, and angiogenesis. The gene discussed is MALAT1; the disease is endothelial dysfunction.