MAN1C1 and cat-eye syndrome: [69] MAN1C1 is a target downregulated by TNF-α, and the activated receptor PPARΥ can mediate its anti-inflammatory effects.[70] It can be inferred from the above that the use of the nomogram generated by the expression of these 5 characteristic genes may help diagnose and prevent CES through serum detection at a relatively early clinical stage, thus reducing the incidence rate and complications of CES, which is also the next research direction of this research group.