[69] MAN1C1 is a target downregulated by TNF-α, and the activated receptor PPARΥ can mediate its anti-inflammatory effects.[70] It can be inferred from the above that the use of the nomogram generated by the expression of these 5 characteristic genes may help diagnose and prevent CES through serum detection at a relatively early clinical stage, thus reducing the incidence rate and complications of CES, which is also the next research direction of this research group. This evidence concerns the gene TNF and cat-eye syndrome.