Immune infiltration analysis using MCPcounter, EPIC, CIBERSORTx, and xCell demonstrated a strong positive correlation between COL10A1 expression and CAF or M2 macrophage abundance across all cancer types, while negative correlations were observed with CD8+ T cells and activated NK cells, although with variable significance across cancers (Fig. 10D). The gene discussed is COL10A1; the disease is cancer.