Spatial transcriptomic analysis revealed that COL10A1+Fib co-localized with regions enriched in EMT signatures, M2 macrophages, and high tumor cell density across all eight analyzed cancers (excluding esophageal cancer, for which ST data was not available) (Supplementary Fig. 16) These findings suggest a potential role for COL10A1+Fib in metastasis-related and immune-evasive processes. The gene discussed is COL10A1; the disease is esophageal cancer.