While GREM1low PDACs showed a trend towards perineural invasion (TC: p = 0.06, Fig. 4A) and blood vessel infiltration (V0 vs. V2: p = 0.06, Fig. 4B), expression of any of the signalling molecules in PDAC (TC and TF) was not significantly associated with the presence of extracapsular extension of lymph node (LN) metastases, lymphovascular (“L1”) or perineural invasion (“Pn1”), tumour stage or tumour grade. This evidence concerns the gene TF and neoplasm.