Both PDAC parenchyma and stroma were mostly BMP4low (non-neoadjuvant cases, mean 0.25 mRNA transcripts per tumour cell) with a few parenchymal BMP4high cases (maximum of 6.3 transcripts/tumour cell (TF) in a ATM-mutant pT3 pN1 duct adenocarcinoma [35, 36] with adjuvant FOLFIRINOX [37] and > 5 years overall survival; hyperactive BMP4 signalling described in PDAC with ATM loss [38]; respective tissue core in Figure S1) (Table 2). Here, ATM is linked to bile duct adenocarcinoma.