OPTN and Huntington disease: Mitophagy genes Pink, Parkin, and Optn were measured in SD and HD kidney and found that HD have reduced gene expression for Optn, whereas Pink and Parkin demonstrated a significant increase in gene expression compared to SD control rats.The mitochondrial dysfunction associated with IR was identical in both normal and HD rats with significant alterations in the expression of genes regulating mitochondrial quality, such as mitophagy, mitofission, and fusion.