There was striking overrepresentation of proteins encoded by ALS-associated genes in the proteins with concordant upregulation in insoluble fractions (Cu/Zn superoxide dismutase, TDP-43 and valosin containing protein, OR 16.34, unadjusted p = 0.002; Fig. 4A). The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.