Ubiquitinated neuronal and glial cytoplasmic aggregates of the 43KDa transactive response DNA and RNA binding protein, TDP-43, are the histopathological hallmark in 97% of ALS cases [28], with a strong predilection for the motor cortex and its frontal connectome, and the spinal cord anterior horns. Here, TARDBP is linked to amyotrophic lateral sclerosis.