Upregulated proteins included importin IPO5 (fc = 0.6, FDR-adjusted p = 0.044), NMDA receptor component NME1 (fc = 0.8, FDR-adjusted p = 0.007), valosin containing protein (VCP), rare variants of which are associated with ALS, FTD and multisystem proteinopathy [4, 20] (fc = 0.5, FDR-adjusted p = 0.007) and inflammatory protein ANXA1 (fc = 0.5, FDR-adjusted p = 0.008). Here, VCP is linked to amyotrophic lateral sclerosis.