TARDBP and amyotrophic lateral sclerosis: Comparing detergent-soluble and -insoluble fractions with other disease conditions and with non-neurological control samples, this study sought to understand the TDP-43 specific aggregated proteome in terms of enriched pathways, the relevance of proteins that interact with TDP-43 in the non-disease state and look for the presence of proteins encoded by genes associated with ALS.