In the detergent-soluble fraction of ALS cortex, there were 2 proteins downregulated, the endonuclease SND1 that mediates miRNA decay and is involved in STAT6 pathway (fc = -0.9, FDR-adjusted p = 0.022) and the mitochondrial protein TRAP1 (fc = -0.4, FDR-adjusted p = 0.047) (FDR-adjusted p ≤ 0.05) (Fig. 2B). This evidence concerns the gene SND1 and amyotrophic lateral sclerosis.