Co-incident (though not colocalised) aggregation of SOD1 and TDP-43 has been described in spinal cord motor neurons [39]; other aggregates co-existent with TDP-43 in neurons in ALS are also described, such as dipeptide repeat protein aggregates in C9orf72 ALS [2]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.