These findings highlight a significant connection between TOPK and the immunosuppressive microenvironment of tumors, which led us to further investigate TOPK's role in the tumor immune microenvironment of kidney cancer, which showed that high TOPK expression in KIRC was closely associated with the infiltration of immunosuppressive cells and a deficiency in immune-active cells within the immune microenvironment. This evidence concerns the gene PBK and neoplasm.