PBK and cancer: Furthermore, we investigated the relationship between TOPK expression and pan-cancer immune subtypes, which encompass six categories: Cl (Wound Healing), C2 (IFN-γ Dominant), C3 (Inflammatory), C4 (Lymphocyte Depleted), C5 (Immunologically Quiet), and C6 (TGF-β Dominant) [21] (Fig. S4).