CD8A and neoplasm: To further elucidate the relationship between TOPK and the infiltration of tumor cells within the KIRC, we assessed the single-cell sequencing data from the phs002065.v1.p1 dataset using the U-MAP method and observed that TOPK is correlated with various immune cell types, including CD8 + T cells, helper T cells, tp1, tp2, NK cells, B cells and TAMs (Fig. 6I-K); The GSE121636 dataset containing 3 KIRC samples and 3 control samples was further enrolled.