Therapeutic strategies with few (<10) but effective (>80% with therapeutic effects) evaluations against both pathological tau and cognitive deficits include those targeting tau reduction via antisense oligonucleotides and similar approaches, energy metabolism, neurotrophin/neurotrophin receptor signaling modulation, epigenome/transcription, oxidative stress, and microtubule stabilization (Figure 7). Here, BDNF is linked to Cognitive impairment.