NFKB1 and amyloidosis: The findings of our study, which investigated the relationship between NF-κB and MAPK-mediated proinflammatory microenvironment and amyloid accumulation in the kidneys of aged rats, revealed that aging-related low-grade inflammation induces histopathological changes in renal tissue but is not sufficient for amyloid accumulation in the primary target organs of systemic amyloidosis.