It is thus not surprising that gain-of-function STING mutants including V147L/M, N154S, and V155M cause severe autoinflammatory diseases called STING-associated vasculopathy with onset in infancy (SAVI) and familial chilblain lupus (G166E) (Konig et al, 2017; Patel and Jin, 2019). The gene discussed is STING1; the disease is familial chilblain lupus.