To build a complete 3D genome atlas capturing the full spectrum of tumor development, we analyzed 26,852 cells from 16 replicates across multiple lung lobes (most containing several discrete tumors) of 13 mice harboring all stages of LUAD progression which are as follows: AT2, AdenomaR (red Trp53+/+), AdenomaY (yellow Trp53+/−), AdenomaG (green Trp53−/−) and LUAD cells. The gene discussed is TP53; the disease is neoplasm.