PDX1 and cancer: To study whether the global 3D genome changes in LUAD progression are conserved in another Kras-driven cancer type, we leveraged an analogous K-MADM-Trp53 model of PDAC, which directs Cre recombinase activity to the pancreas using a Pdx1-cre transgene and recapitulates major genetic and histologic events in human PDAC progression30,33,34.