To test this hypothesis, we first constructed ATM knockdown stable cell lines in four TNBC cell lines, MDA-MB-231, HCC1937, SUM159 and BT549, and found that the expression of MHC-I (HLA-A + HLA-B) on the surface of tumor cells was increased by flow cytometry (Fig. 3A–D). This evidence concerns the gene HLA-B and neoplasm.