Furthermore, the SOD3-mediated, anti-inflammatory role in skin inflammation by inhibiting the expression of proinflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8, and SOD1-mediated suppression of proinflammatory immune responses against oxidative stress in colitis, were also reported [64, 65]. Here, CXCL8 is linked to colitis.