In addition, Polo-like kinase 4 (PLK4), a kinase that promotes SAS-6 recruitment to the cartwheel structure (Dzhindzhev et al, 2014; Ohta et al, 2014; Moyer et al, 2015; Arquint & Nigg, 2016), is overexpressed in cancer (Godinho et al, 2014; Godinho & Pellman, 2014) leading to centrosome amplification, increased cell invasion (Godinho et al, 2014), and increased small vesicle secretion (Adams et al, 2021). The gene discussed is PLK4; the disease is cancer.