NSD2 and Miyoshi myopathy: The t(4;14) translocation, involving the IgH (immunoglobulin heavy chain) locus on chromosome 14q32.33 and the NSD2 gene on chromosome 4p16.3, occurs in 15% to 20% of MM cases and is associated with a significantly worse prognosis compared with other genetic subgroups (14, 15, 16).