Multiplex analysis revealed no significant differences in circulating proinflammatory cytokine levels including IL-1β, IL-6, TNFα, CCl2, and IL-12 or anti-inflammatory cytokine IL-10 between ApoE−/−P-Jak2 KO and WT mice after 4 weeks of HCD (Fig. 6). The gene discussed is IL1B; the disease is heavy chain disease.