Similar levels of proinflammatory (IL-1β, IL-6, C, IL-12 (p40), IL-12 (p70), TNFα, CCL-2) and anti-inflammatory (IL-10) cytokines were present between the ApoE−/−P-Jak2 KO mice and their WT controls after 4 weeks of HCD. This evidence concerns the gene APOE and heavy chain disease.