However, we found that PD-1 signaling had no significant inhibitory effect on the above cytokines in RA CD4+PD-1+T cells, but instead potentiated the upregulation of pathogenic inflammatory mediators, including IL-6, IL-17A, and CXCL13 (Fig. 7D). The gene discussed is CXCL13; the disease is rheumatoid arthritis.