Furthermore, enhanced mitophagy by CCCP significantly attenuated the production of SASP-related cytokines (IL-21, CXCL13, IFN-γ, and TNF-α) and cytotoxic molecules (Perforin and Granzyme B) in RA CD4+PD-1+T cells (Fig. S9) and CD4+PD-1+ Jurkat cells (Fig. 6F). This evidence concerns the gene PDCD1 and rheumatoid arthritis.