Correlations in expression programs with PRRs showed in platelets the thrombolysis-inhibiting SERPINE1 [39] (encoding for plasminogen activator inhibitor, PAI-1) positively correlated with TLR9 and MDA5 without infection, and during SARS-CoV-2 infection SERPINE1 correlated positively with MDA5 and RIG-I and negatively with TLR5. The gene discussed is SERPINB2; the disease is infection.