Additionally, in COVID19 patients, platelet-SELP positively correlated with the highest number of leukocyte PRRs, including leukocyte-TLR2, -TLR3, -TLR4, -TLR6, -TLR8, -RIG-I and -CGAS (Fig 5F and S16 Table). This evidence concerns the gene TLR4 and COVID-19.