Host proteins enriched at cellular replication forks during infection included DNA processing factors such as GINS, TOP2A, PRIM1/2, RPA2 and XRCC1; DDR signaling proteins such as CSNK2A1/3; cell cycle regulator proteins such as TFDP2 and SFN1; as expected for cells undergoing replication stress. Here, XRCC1 is linked to infection.