As a recently discovered hotspot, EXT1 has been confirmed to be widely expressed in various membranous nephropathies, including lupus membranous nephropathy (LMN), primary membranous nephropathy (PMN), and PLA2R-negative membranous nephropathy and indicates a favorable prognosis [28–34]. This evidence concerns the gene PLA2R1 and membranous glomerulonephritis.