Considering P21’s dual role as an anti-cancer factor with potential pro-cancer effects linked to tumor proliferation, migration, and invasion, leading to unfavorable patient prognosis, it is highly conceivable that SLC2A1 may modulate LUAD proliferation, migration, invasion, and apoptosis through the P53 signaling pathway, thereby influencing LUAD prognosis. This evidence concerns the gene TP53 and neoplasm.