<h4>Introduction</h4>The present study assessed the impact of the disposable Simplera SyncTM sensor with the MiniMedTM 780G (MM780G) advanced hybrid closed-loop (AHCL) system on type 1 diabetes (T1D) glycemic metrics, insulin delivery, and safety.<h4>Materials and methods</h4>Youths (aged 7-17 years) and adults (aged 18-80 years) with T1D were enrolled in this single-arm, nonrandomized study at 24 sites in the United States. Here, INS is linked to type 1 diabetes mellitus.