CD274 and colorectal cancer: Given that we consistently observed an inverse relationship between GALNT7 and PD-L1 levels in dMMR/MSI colorectal cancers—but not in pMMR/MSS colorectal cancers—across multiple transcriptomic, proteomic, and IHC datasets (Figs. 2J–M, and 3J), we hypothesized that GALNT7 negatively regulates PD-L1 expression in dMMR/MSI colorectal cancer cells.