In addition to these direct immunosuppressive effects mediated by glycans via lectin interactions, N-glycosylation of PD-L1 protein on cancer cells, likely through dysregulation of glycosyltransferases, can also contribute to the immune evasion by stabilizing PD-L1 protein structure and potentiating the PD-1/PD-L1 axis (16–18). This evidence concerns the gene CD274 and cancer.