As shown in Fig. 1A and Supplementary Table S3, this analysis identified five glycosyltransferase genes, namely, ST6GAL1, GALNT6, HPSE, GALNT1, and GALNT7, expression of which was consistently upregulated or downregulated in MSI colorectal cancer tissues, cell lines, and single epithelial cells compared with MSS colorectal cancers. The gene discussed is HPSE; the disease is colorectal cancer.