The cellular prion protein (PrPC), a membrane glycoprotein abundant in neurons, undergoes pathogenic misfolding into the β-sheet-rich isoform PrPSc in prion diseases (Miranzadeh Mahabadi and Taghibiglou 2020; Cha and Kim 2023; Baral et al. 2019). The gene discussed is PRNP; the disease is prion disease.