TDP-43 pathology is also present in approximately 19–57% of Alzheimer's disease (AD) cases and 75% of severe AD cases (Josephs et al., 2014; Uryu et al., 2008), and the prevalence of TDP-43 in AD increases with age (Jo et al., 2020). Here, TARDBP is linked to early-onset autosomal dominant Alzheimer disease.