Overexpression models of TDP-43 have been recently criticised in ALS/FTD (Carmen-Orozco et al., 2024) because high levels of TDP-43 expression in mice result in skipping of constitutive exons that are typically included in mRNAs under normal conditions (Carmen-Orozco et al., 2023; Carmen-Orozco et al., 2024). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.