TARDBP and amyotrophic lateral sclerosis: Whilst several therapeutic interventions for ALS have been previously examined in TDP-43 rNLS8 mice (Luan et al., 2023; Riemenschneider et al., 2023; Spiller et al., 2019; Tsitkanou et al., 2022; Wright et al., 2021), they have had limited success.