We found that hepatocyte-specific Kdm5b KO was as effective as CMV-Cre KO in preventing fibrosis development in alcohol-fed mice after 8 weeks of feeding (Figures 1G, I), and hepatocyte-specific Kdm5b KO greatly reduced liver fibrosis development after 16 weeks as well (Figures 1H, I). Here, KDM5B is linked to Hepatic fibrosis.