Alternatively, through proteomics of stool from cwCF compared to stool of their non-CF siblings, Debyser et al. showed that two microbial proteins involved in butyrate production originating from F. prausnitzii, 3-hydroxybutyryl-CoA dehydrogenase and acetyl-CoA acetyltransferase, are decreased in CF (47), consistent with the observation that SCFA producers and their functional proteins are decreased in CF microbiomes. Here, ACAA2 is linked to cystic fibrosis.