NR1H4 and obesity due to melanocortin 4 receptor deficiency: Interestingly, treating high-fat diet-fed and ob/ob mice, two different models of type 2 diabetes and obesity, with P. distasonis CGMCC1.30169 reduced weight gain, hyperglycemia, and hepatic steatosis by activating intestinal gluconeogenesis and FXR pathways (Wang et al. 2019).