Moreover, PIK3R1 was identified as one of the key immune hub genes closely associated with tau and Aβ pathology in AD, with its involvement linked to abnormal peripheral immune cell infiltration and pathways such as axon guidance, long‐term potentiation, and cytokine–cytokine receptor interactions (Mei et al. 2006). The gene discussed is PIK3R1; the disease is Alzheimer disease.