Furthermore, meta‐analyses and network‐based studies identified PIK3R1 as a hub gene in T2DM‐related pathways, including PI3K‐Akt signaling, linking it to key metabolic and cellular processes (Zhu et al. 2020; Rasche et al. 2008; Zhang et al. 2024). This evidence concerns the gene AKT1 and type 2 diabetes mellitus.