This is significant because Tau phosphorylation is observed in both 5XFAD mice and AD patients, and pTau levels correlate with cognitive decline in AD patients.[28, 29] These results indicate that CRB‐2131 inhibits pTau levels in the brain of 5XFAD mice (Figures 2E and 3A). The gene discussed is MAPT; the disease is Alzheimer disease.