RAPGEF3 and keloid: A representative example is circCOL5A1, which acts as a sponge for miR‐877‐5p to regulate keloid progression via the circCOL5A1/miR‐877‐5p/EGR1 axis;[38] or for miR‐7‐5p, thereby modulating the keloids through the circCOL5A1/miR‐7‐5p/Epac1 axis.[39] These findings highlight the essential role of circRNAs in the regulation of wound repair, scars, and keloids through complex networks.