CREB1 and neoplasm: Moreover, the three significantly downregulated DEGs downstream of the hsa_circ_00 26782/CREB1 axis (DUSP9, LDLR, and PHLDA1) have been reported in multiple studies to be closely associated with various types of cancer,[63, 64, 65, 66, 67] inflammation,[66, 68, 69] and fibrosis.[70, 71] These findings further support the notion that keloids exhibit tumor‐like properties, excessive inflammation, and fibrotic features, and highlight the biological relevance of hsa_circ_00 26782 both in vitro and in vivo.