reported that CREB1‐driven CXCR4(high) neutrophils promote skin inflammation in both mouse models and human patients.[62] Our study reveals that the hsa_circ_00 26782/CREB1 axis may play a crucial role in the progression of keloids, providing strong evidence supporting the notion that “keloids are a kind of inflammatory skin disease with tumor‐like properties”. This evidence concerns the gene CXCR4 and inflammatory skin disease.