In the placenta, IFN secretion and the corresponding ISG induction promote spiral artery remodeling and virus restriction.[4, 5] On the contrary, elevated IFN levels in interferonopathies including “TORCH” infections (toxoplasmosis, other, rubella, cytomegalovirus, and herpes) and genetic interferonopathies (i.e., Aicardi‐Goutières syndrome (AGS), Down syndrome in trisomy 21, and systemic lupus erythematosus) are linked to pregnancy complications,[4, 6, 7, 8] suggesting that IFN activation is a double‐edged sword for a successful pregnancy. The gene discussed is IFNA1; the disease is Down syndrome.