IFNA1 and infection: In addition to our findings, compelling pieces of evidence have repeatedly shown that both “TORCH” infections and genetic interferonopathies with high IFN levels are strongly associated with adverse pregnancy outcomes.[4, 6, 7, 8] However, blocking IFN may be an ill‐advised strategy to mitigate pregnancy complications linked to interferonopathies, since it would indiscriminately suppress constitutively expressed ISGs in the placenta, potentially rendering the conceptus susceptible to viral invasion.