Univariate analysis showed that gender, pulmonary heart disease, white blood cell count, neutrophil count, lymphocyte count, monocyte count, eosinophil count, basophil count, platelet count, hemoglobin, RDW, albumin, NT-proBNP, CRP, and inflammatory indices (NLR, PLR, MLR, ELR, BLR, SII) were significantly associated with AECOPD (P < 0.001). This evidence concerns the gene ALB and cor pulmonale.