Crucially, sex-stratified analyses revealed divergent response patterns: in men, both CRP ≥ 40 mg/L and the 72-h time point were linked to higher ALT levels, and elevated white blood cell count and neutrophil–lymphocyte ratio predicted GGT increases; in women, AST declined over time and was inversely correlated with CRP at 10–40 mg/L and ≥ 40 mg/L, ALT elevation was attenuated only in the CRP ≥ 40 mg/L subgroup, and GGT expression decreased in the presence of leukocytosis and rising NLR. Here, GPT is linked to Increased total leukocyte count.