IL10 and major depressive disorder: In contrast, the anti-inflammatory cytokine interleukin-10 (IL-10) was significantly decreased in depressed patients (1.2 vs. 2.4 pg./mL, d = −1.21, p = 0.003), and was inversely associated with depression (OR = 0.62, 95% CI: 0.46–0.83), highlighting impaired anti-inflammatory buffering in this subgroup.