In arteriosclerosis obliterans (peripheral arterial presentation of atherosclerosis), downregulation of the Grb2-associated binder 1 (GAB1) protein has been shown to significantly increase autophagy in ECs through activation of the MAPK pathways, which in turn inhibit cell proliferation and migration (Qian et al., 2020). The gene discussed is GAB1; the disease is arteriosclerosis obliterans.