SIPA1L2 and atherosclerosis: Endothelial colony-forming cells are ECs that mediate vascular repair and secrete exosomes containing miR-21-5p in atherosclerosis; these exosomes deliver miR-21-5p to target signal induced proliferation associated 1 like 2 (SIPA1L2) that interacts with LC3 and rescues autophagy in the ECs (Ke et al., 2022).