ERVW-1 and neoplasm: To explore the impact of the HERV-K env on the genesis of EOC cell lines, the HERV-K env gene was knocked out in EOC cell lines SKOV3 and OVCAR3 through the CRISPR-Cas9 system, which indicated dramatic attenuation of tumor cell proliferation, migration, and invasion (Ko et al., 2022; Ko et al., 2024).