FOXO1 and neoplasm: Moreover, studies reporting higher prevalences of LNM among both RMS and patients with NRSTS tended to include more advanced disease populations, characterised in the RMS group by alveolar histology,24PAX3/PAX7–FOXO1 fusion positivity,61, 62, 63 older patients,64, 65, 66 and larger tumours,15,28,29,67, 68, 69 and in the NRSTS group by specific histologic subtypes (e.g., DSRCT) and more invasive tumours.31