SNCA and Parkinson disease: ENT-01, also known as squalamine phosphate, acts by displacing alpha-synuclein electrostatically bound to nerve cell membranes and has been shown to prevent the aggregation of alpha-synuclein monomers both in vitro and in vivo.182 Additionally, it stimulates enteric neurons and improves GI motility in PD mouse models.183 Two Phase 2 studies of ENT-01 for constipation in PD have been published.