S100A12 and Sepsis: The MRP-126 gene found in reptiles and birds is an orthologue to mammalian S100-A12 belonging to the S100/calgranulin family of proteins (Loes et al., 2018) and S100-A12 is considered a pro-inflammatory modulator used as a biomarker of cellular damage, trauma and sepsis in mammals (Meijer et al., 2012; Khorramdelazad et al., 2015; Dubois et al., 2019; Zornow et al., 2023).