However, considering that PIEZO1 DNA hypomethylation has been associated with dysfunctional brain functioning, such as in Alzheimer’s disease (Li et al., 2022; Velasco-Estevez et al., 2018), we expected that infants with NDs would exhibit lower PIEZO1 DNAm levels compared to infants with TD. This evidence concerns the gene PIEZO1 and early-onset autosomal dominant Alzheimer disease.