IGHE and Alzheimer disease: As demonstrated in a birth cohort study, prenatal mold exposure increased the odds of developing AD in infancy by 36% (adjusted OR 1.36; 95% CI 1.01–1.83), with exposed infants exhibiting significantly higher total serum IgE levels at 1 year of age (124.96 ± 413.82 kU/L) compared to unexposed healthy infants (58.71 ± 126.25 kU/L), suggesting an IgE-mediated mechanism of allergic inflammation (81).